Goldman Sachs showed its support of the Supreme Court's same-sex marriage ruling this summer by flying a rainbow flag outside of its offices.
NEW YORK (CNNMoney) It's been a record year for gay rights.Not only did the Supreme Court overturn the Defense of Marriage Act, the law preventing same-sex couples from receiving federal spousal benefits, but hundreds of American corporations have been rallying for the cause, publicly supporting same-sex marriage and ramping up benefits and protections for lesbian, gay, bisexual and transgender employees.
Heading into 2014, a record 304 U.S. companies boast perfect "corporate equality" scores of 100 from the Human Rights Campaign, according to the LGBT advocacy group's new report examining more than 900 businesses on 40 different policies and practices. That's up from 252 perfect scores last year and 189 two years ago.
Best Quality Companies To Own In Right Now: Biox Corp(BX.TO)
BIOX Corporation, a renewable energy company, engages in the design, building, ownership, and operation of a biodiesel production facility in Canada. It produces biodiesel from various feedstock, including recycled vegetable oils, agricultural seed oils, yellow greases, and tallow. The company was incorporated in 2000 and is headquartered in Oakville, Canada.
Best Quality Companies To Own In Right Now: Inovio Pharmaceuticals Inc (INO)
Inovio Pharmaceuticals, Inc., incorporated on June 29, 1983, is engaged in the development of a new generation of vaccines, called synthetic vaccines, focused on cancers and infectious diseases. The Company's SynCon technology enables the design of universal vaccines capable of providing cross-protection against existing or changing strains of pathogens, such as influenza and human immunodeficiency virus (HIV). The Company's electroporation delivery technology uses brief, controlled electrical pulses to increase cellular uptake of the vaccine. Its clinical programs include cervical dysplasia (therapeutic), avian influenza (preventive), prostate cancer (therapeutic), leukemia (therapeutic), hepatitis C virus (HCV) and HIV vaccines. It is advancing preclinical research and clinical development for a universal seasonal/pandemic influenza vaccine, as well as preclinical work for other products, including malaria and prostate cancer vaccines. Its partners and collaborators include University of Pennsylvania, Drexel University, National Microbiology Laboratory of the Public Health Agency of Canada, Program for Appropriate Technology in Health/Malaria Vaccine Initiative (PATH/MVI), National Institute of Allergy and Infectious Diseases (NIAID), Merck, ChronTech, University of Southampton, United States Military HIV Research Program (USMHRP), the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) and HIV Vaccines Trial Network (HVTN). As of December 31, 2011 it owned 16.1% interest in VGX Int��.
Inovio�� Solution
The Company�� synthetic vaccine platform consists of its SynCon vaccine design process and electroporation delivery technology. It has developed a preclinical and clinical stage pipeline of vaccines. The Company�� synthetic vaccines are designed to prevent a disease (prophylactic vaccines) or treat an existing disease (therapeutic vaccines). Its synthetic vaccine consists of a deoxyribonucleic acid (DNA) plasmid encoding a selected antigen! (s), which is introduced into cells of humans or animals with the purpose of evoking an immune response to the encoded antigen. The Company�� synthetic vaccines are designed to generate specific antibody and/or T-cell responses.
The Company�� SynCon technology provides processes that employ bioinformatics, which combine extensive genetic data and sophisticated algorithms. Its design process uses the genetic make-up of a common antigen(s) from multiple strains of a virus within a viral sub-type or taxonomic group (family) of pathogens, such as HIV, hepatitis C virus (HCV), human papillomavirus (HPV), influenza and other diseases to synthetically create a new antigen for the desired pathogen target that does not exist in nature. Its synthetic vaccine candidates are being delivered into cells of the body using its electroporation (EP) DNA delivery technology.
Cancer Synthetic Vaccines
The Company has two broad types of cancer vaccines: preventive (or prophylactic) vaccines, which are intended to prevent cancer from developing in healthy people, and treatment (or therapeutic) vaccines, which are intended to treat an existing cancer by strengthening the body�� natural defenses against the cancer. Two types of cancer preventive vaccines are available in the United States. The United States Food and Drug Administration (the FDA) has approved two vaccines, Gardasil and Cervarix that protect against infection by the two types of HPV-types 16 and 18-that cause approximately 70% of all cases of cervical cancer worldwide. In addition, Gardasil protects against infection by two additional HPV types, 6 and 11, which are responsible for about 90% of all cases of genital warts in males and females but do not cause cervical cancer.
Cervarix manufactured by GlaxoSmithKline, is composed of virus-like particles (VLPs) made with proteins from HPV types 16 and 18. Cervarix is approved for use in females��ages 10 to 25 for the prevention of cervical cancer caused by! HPV type! s 16 and 18. Gardasil manufactured by Merck, is approved for use in females for the prevention of cervical cancer, and some vulvar and vaginal cancers, caused by HPV types 16 and 18 and for use in males and females for the prevention of genital warts caused by HPV types 6 and 11. The vaccine is approved for these uses in females and males ages 9 to 26. The FDA has also approved a cancer preventive vaccine that protects against hepatitis B virus (HBV) infection.
Inovio�� VGX-3100 is designed to raise immune responses against the E6 and E7 genes of HPV types 16 and 18 that are present in both pre-cancerous and cancerous cells transformed by these HPV types. E6 and E7 are oncogenes that play an integral role in transforming HPV-infected cells into cancerous cells. In March 2011, it initiated a randomized, double-blind Phase II study of VGX-3100 delivered using the CELLECTRA intramuscular electroporation device in women with HPV Type 16 or 18 and diagnosed with, but not yet treated for, cervical intraepithelial neoplasia (CIN) 2/3. The study is designed to enroll 148 subjects. In January 2011, it announced the publication of a scientific paper in the journal Human Vaccines detailing potent immune responses in a preclinical study of its SynCon vaccine for prostate cancer targeting two antigens, prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA).
In January 2011, the Company announced the regulatory approval of a Phase II clinical trial (WIN Trial) to treat leukemia utilizing its new ELGEN 1000 automated vaccine delivery device. The single dose level, Phase II study, called WT1 immunity via DNA fusion gene vaccination in haematological malignancies by intramuscular injection followed by intramuscular electroporation. Cancer Vaccines encodes for hTERT, an antigen related to non-small cell lung, breast and prostate cancers. The vaccine is delivered using its electroporation delivery technology.
Infectious Disease Synthetic Vaccines
In Marc! h 2011, the Company announced the initiation of a follow-on open label, single dose Phase II clinical study in collaboration with ChronTech of the ChronVac-C HCV DNA vaccine delivered using its electroporation technology in treatment naive HCV infected individuals. Its HIV vaccines consist of candidates for HIV prevention, as well as therapy or treatment. PENNVAX-B is designed to target HIV clade B (most commonly found in the United States, North America, Australia and the European Union (EU). PENNVAX-G is designed to target HIV clades A, C and D, which are more commonly found in Asia, Africa, Russia and South America. This Phase I clinical study of PENNVAX-B (HVTN-080) vaccinated 48 healthy, HIV-negative volunteers to assess safety and levels of immune responses generated by Inovio�� PENNVAX-B vaccine delivered with its CELLECTRA electroporation device. PENNVAX-B is a SynCon vaccine that targets HIV gag, pol, and env proteins.The Company�� VGX-3400X targets H5N1. The vaccine consists of three distinct DNA plasmids coded for a consensus hemagglutinin (HA) antigen derived from different H5N1 virus strains; a consensus neuraminidase (NA) antigen derived from different N1 sequences; and a consensus nucleoprotein (NP) fused to a small portion of the m2 protein (m2E) based on a broader cross-section of influenza viruses in addition to H5N1 and H1N1. Conventional vaccines are strain-specific and have limited ability to protect against genetic shifts in the influenza strains they target. They are therefore modified annually in anticipation of the next flu season�� new strain(s). It is focused on developing DNA-based influenza vaccines able to provide broad protection against known as well as newly emerging, unknown seasonal and pandemic influenza strains.
Animal Health/Veterinary
VGX Animal Health, Inc. (VGX AH), a majority-owned subsidiary, has licensed LifeTide, a plasmid-based growth hormone releasing hormone (GHRH) technology for swine. LifeTide is one of onl! y four DN! A-based treatments approved for use in animals and is the only DNA-based agent delivered using electroporation that has been granted marketing approval (Australia). VGX AH is also developing a GHRH-based treatment for cancer and anemia in dogs and cats. It is developing a synthetic vaccine for foot-and-mouth disease (FMD) administered by its vaccine delivery technology. The FMD virus is one of the most infectious diseases affecting farm animals, including cattle, swine, sheep and goats, and is a serious threat to global food safety.
The Company competes with Crucell N.V, Sanofi-Aventis, Novartis, Inc., GlaxoSmithKline plc, Merck, Pfizer, AstraZeneca, Inc., Novartis, Inc., MedImmune and CSL.
Advisors' Opinion:- [By George Budwell]
Inovio Pharmaceuticals (NYSEMKT: INO ) develops DNA-based vaccines and delivers them using a proprietary electroporation technique. Shares of Inovio have been a roller coaster all year long, and have certainly been the playground of day traders. Last week, Inovio shares lost more than 10% of their value on heavy volume, suggesting the stock may continue to experience downward pressure. This rapid move downward is surprising because the company recently signed a licensing deal with Roche (NASDAQOTH: RHHBY ) to commercialize Inovio's multi-antigen DNA immunotherapies for prostate cancer and hepatitis B. As part of the deal, Inovio received $10 million upfront, and milestone payments could go as high as $412 million.
Best Stocks To Invest In: UTStarcom Inc.(UTSI)
UTStarcom Holdings Corp. designs and sells Internet protocol (IP)-based telecommunications infrastructure products to telecommunications service providers and operators worldwide. It provides solutions in IPTV, interactive (iD) TV, Internet TV, and broadband, as well as related installation and maintenance services. It offers multimedia communications products, including RollingStream, an IPTV solution that enables a service provider to deliver broadcast television and on-demand video services to residential and commercial premises over a switched network architecture; mSwitch, a next generation network solution that enables service providers to migrate from existing circuit platforms to a next generation IP-based switch architecture, or to launch new applications in new deployment environments that have no legacy infrastructure; and a personal access system, as well as provides related consulting, technical, project, quality, and maintenance support-level services. The co mpany also provides broadband infrastructure products comprising broadband access products consisting of multi-service access node products; digital subscriber line (DSL) products, such as DSL modems, set-top boxes, and voice over the internet devices for residential and business customers; and gigabit Ethernet passive optical network products, as well as optical transport products, including packet optical transport network products, multi-service transport platform, and resilient packet ring. It sells its products through direct sales, original equipment manufacturers, distributors, resellers, agents, and licensees primarily in China, Japan, India, and other Asian markets; the United States; Latin America; and Europe. The company was formerly known as UTStarcom, Inc. and changed its name to UTStarcom Holdings Corp. in June 2011. UTStarcom Holdings Corp. was founded in 1991 and is headquartered in Beijing, China.
Advisors' Opinion:- [By Dan Radovsky]
Today the satellite pay-TV provider filed a letter with the Federal Communications Commission pointing to media reports about a Department of Justice investigation into charges of bribery by telecommunications equipment provider UTStarcom (NASDAQ: UTSI ) , also known as UTSI. The DOJ says the company gave $7 million to Chinese government officials in return for telecommunications sales contracts. In 2009 UTStarcom admitted to bribery and agreed to pay $1.5 million.
- [By Dan Radovsky]
DISH's reply
As expected, DISH was ready with a response, but it wasn't one that defended its numbers. Instead, DISH filed a letter with the Federal Communications Commission repeating media accounts regarding a Department of Justice investigation of bribery charges against telecommunications equipment provider UTStarcom (NASDAQ: UTSI ) . The DISH filing says Masayoshi Son was chairman of the board of UTStarcom during part of the time in which the bribery was said to occur.
Best Quality Companies To Own In Right Now: New York & Company Inc.(NWY)
New York & Company, Inc., together with its subsidiaries, operates as a specialty retailer of women's fashion apparel and accessories in the United States. The company offers a range of wear-to-work, and casual apparel and accessories, including pants, jackets, knit tops, blouses, sweaters, denim, T-shirts, activewear, handbags, and jewelry. It sells its products under the New York & Company, Lerner, Lerner New York, New York Style, City Stretch, City Style, and NY&C brand names. The company sells its branded merchandise through its network of retail stores and E-commerce store at nyandcompany.com. As of March 15, 2012, it operated 532 stores in 43 states. The company, formerly known as NY & Co. Group, Inc., was founded in 1918 and is headquartered in New York, New York.
Advisors' Opinion:- [By Anna Prior]
New York & Co(NWY).’s fiscal third-quarter loss narrowed as the women’s apparel retailer recorded comparable-store-sales growth and benefited from lower costs.
- [By Jeremy Bowman]
What: Shares of New York & Company (NYSE: NWY ) were looking sharp, gaining as much as 10% two market days after reporting earnings, as Janney Montgomery Scott today reaffirmed its buy rating and upped its price target by 50% to $6.
Best Quality Companies To Own In Right Now: ACCSYS TECHNOLOGIES ORD EUR0.01(AXS.L)
Accsys Technologies PLC, together with its subsidiaries, engages in the development and commercialization of various technologies for the manufacture of Accoya branded acetylated wood in the United Kingdom. It also engages in the ownership and exploitation of intellectual property rights relating to the acetylation of cellulose and the production of acetic anhydride; provision of technical and engineering services to licensees; technical development of fiber board opportunities; manufacture of Accoya, the acetylated wood; and provision of sales, marketing, and technical services. The company is based in London, the United Kingdom.
Best Quality Companies To Own In Right Now: Cimpor Cimentos de Portugal SGPS SA (CPR.LS)
Cimpor Cimentos de Portugal SGPS SA is a Portugal-based holding company engaged in the construction materials sector. The Company is primarily active in the production and sale of cement and clinker. It also involved in the manufacturing and marketing of ready-mix concrete, dry mortars and aggregates. As of December 20, 2012, the Company operated in Portugal, Egypt, Cape Verde, Angola, Mozambique, South Africa, Brazil, Argentina and Paraguay. The Company�� investments are held essentially through two subsidiaries: Cimpor Portugal SGPS SA, which holds the investments in companies dedicated to the production of cement, concrete, aggregates and mortar in Portugal, and Cimpor Inversiones SA, which holds the investments in companies operating abroad.
Best Quality Companies To Own In Right Now: Delcath Systems Inc.(DCTH)
Delcath Systems, Inc., a development stage company, operates as a specialty pharmaceutical and medical device company. It focuses on cancers in the liver. The company involves in the development and clinical study of the Delcath chemosaturation system. Its clinical trial include a Phase III multi-center study for patients with unresectable metastatic ocular or cutaneous melanoma exclusively or predominantly in the liver; and a multi-arm Phase II clinical trial of the Delcath chemosaturation system with melphalan in patients with primary and metastatic liver cancer, which comprise neuroendocrine tumors, hepatocellular carcinoma, ocular or cutaneous melanoma, and metastatic adenocarcinoma. Delcath Systems, Inc. was founded in 1988 and is based in New York, New York.
Advisors' Opinion:- [By John Udovich]
Biotech in general has been one of the market�� hottest sectors this year thanks to plenty of mostly good news�along with�new IPOs while small cap biotech stocks Delcath Systems (NASDAQ: DCTH), ZIOPHARM Oncology Inc (NASDAQ: ZIOP), Recro Pharma (NASDAQ: REPH), TetraLogic Pharmaceuticals (NASDAQ: TLOG)�and TNI BioTech (OTCMKTS: TNIB) have also produced their share of news�this week or in recent weeks. Just consider the following:
Best Quality Companies To Own In Right Now: Lustros Inc (LSTS)
Lustros, Inc., incorporated on July 30, 1980, is a development-stage company. The Company manufactures copper sulfate from traditional mining and leftover tailings. The Company's manufacturing facilities are located in Chile, South America. In October 2013, Lustros Inc announced that its subsidiary, Sulfatos Chile SA, completed its first sale of Pentahyrdate Copper Sulfate.
On June 25, 2012, the Company created a new subsidiary, Mineraltus S.A. (Mineraltus). The Company owns 80% interest of Mineraltus. On August 22, 2012, the Company formed Lustros Chile SpA as a 100% owned subsidiary. On March 25, 2012, the Company sold the assets (including the Power-Save name) of its renewable energy and energy savings product business.
Best Quality Companies To Own In Right Now: NB&T FINANCIAL GROUP INC(NBTF)
NB&T Financial Group, Inc. operates as a bank holding company for The National Bank and Trust Company that provides commercial banking and financial services to individuals and corporate customers in southwestern Ohio. The company offers various deposit products, including checking accounts, savings accounts, money market deposit accounts, and term certificate accounts. Its loan portfolio includes commercial and industrial loans, such as loans to automobile dealers and loans guaranteed by the small business administration; loans secured by commercial real estate; real estate construction loans for constructing commercial and residential buildings; agricultural loans, including loans to finance farm operations, equipment purchases, and land acquisition; loans secured by one- to four-family residential real estate and multifamily real estate; and consumer installment loans, such as home equity loans, automobile loans, recreational vehicle loans, and overdraft protection. The company also offers credit card services; and trust services that consists of trust administration, investment purchase and management, estate planning and administration, tax and financial planning, and employee benefit plan administration. As of December 31, 2010, it operated a main office in Wilmington, as well as 23 full-service branch offices and 1 remote drive-through automated teller machine facility in Brown, Clermont, Clinton, Highland, Montgomery, Warren, and Cuyahoga counties in Ohio. The company was founded in 1859 and is based in Wilmington, Ohio.
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